Mind your media.

@article{Lagziel2020MindYM,
  title={Mind your media.},
  author={Shoval Lagziel and Eyal Gottlieb and Tomer Shlomi},
  journal={Nature metabolism},
  year={2020}
}

A functional analysis of 180 cancer cell lines reveals conserved intrinsic metabolic programs

This analysis indicates that in absence of variations imposed by the microenvironment, cancer cells adopt distinct metabolic programs which serve as vulnerabilities for therapy.

Determining the temporal, dose, and composition effects of nutritional substrates in an in vitro model of intrahepatocellular triglyceride accumulation

Investigating the effect of modifying media composition, concentration, and treatment frequency of sugars, FAs and insulin on intrahepatocellular triglyceride content and intracellular glucose, FA and circadian function in hepatocytes resulted in a cellular model displaying characteristics of early stage NAFLD seen in humans.

Physiological media advance cell culture experiments.

  • M. Fischer
  • Biology
    Trends in biochemical sciences
  • 2022

Novel insights into the regulation of cellular catabolic metabolism in macrophages through nuclear receptors

Recent developments about nuclear receptors and their role in cellular metabolism in macrophages are highlighted to have new implications for understanding of how NRs shape immune responses and inform anti‐inflammatory drug design.

Drug combination prediction for cancer treatment using disease-specific drug response profiles and single-cell transcriptional signatures

The combination of kinase inhibitors QL-XII-47 and GSK-690693 is identified as the topmost promising candidate for TNBC treatment and the new computational approach allows the identification of drugs and drug combinations targeting specific tumor cell types and subpopulations in individual patients.

Epithelial-mesenchymal transition status is the main driver of intrinsic metabolism in cancer cell lines

In absence of variations imposed by the microenvironment, the metabolism of cancer cell lines falls into only two major classes despite genetic heterogeneity, and a thorough integration of metabolic data with multiple omics data revealed a strong association with markers of epithelial-mesenchymal transition.

Epithelial-mesenchymal transition is the main driver of intrinsic metabolism in cancer cell lines

In absence of variations imposed by the microenvironment, the metabolism of cancer cell lines falls into only two major classes despite genetic heterogeneity, and a thorough integration of metabolic data with multiple omics data revealed a strong association with markers of epithelial-mesenchymal transition.

The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells

These results improve the understanding of serine metabolism in physiologically relevant nutrient conditions and allow us to predict interventions that may enhance the therapeutic response to dietary serine/glycine limitation.

Metabolic Plasticity Aids Amphotropism of Coxiella burnetii

The study underscores that gluconeogenic capacity aids C. burnetii amphotropism and that the amphotropic nature of C.Burnetii should be considered when resolving virulence mechanisms in this pathogen.

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A physiological medium improves the metabolic fidelity and biological relevance of in vitro cancer models and reveals that breast cancer spheroids grown in Plasmax approximate the metabolic profile of mammary tumors better.

Medicine in the digital age

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    Nature Medicine
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As Nature Medicine celebrates its 25th anniversary, we bring you a special Focus on Digital Medicine that highlights the new technologies transforming medicine and healthcare, as well as the related

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