Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.

@article{Itoh2003MindBI,
  title={Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.},
  author={M. Itoh and Cheol-Hee Kim and G. Palardy and T. Oda and Yun-Jin Jiang and Donovan Maust and S. Yeo and K. Lorick and G. Wright and L. Ariza-McNaughton and A. Weissman and Julian Lewis and S. Chandrasekharappa and A. Chitnis},
  journal={Developmental cell},
  year={2003},
  volume={4 1},
  pages={
          67-82
        }
}
Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneural gene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and… Expand
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TLDR
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TLDR
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