MinK-dependent internalization of the IKs potassium channel.

  title={MinK-dependent internalization of the IKs potassium channel.},
  author={Xianghua Xu and Vikram A. Kanda and Eun Hyun Choi and Gianina Panaghie and Torsten Kai Roepke and Stephen A. Gaeta and David J. Christini and Daniel J. Lerner and Geoffrey W. Abbott},
  journal={Cardiovascular research},
  volume={82 3},
AIMS KCNQ1-MinK potassium channel complexes (4alpha:2beta stoichiometry) generate IKs, the slowly activating human cardiac ventricular repolarization current. The MinK ancillary subunit slows KCNQ1 activation, eliminates its inactivation, and increases its unitary conductance. However, KCNQ1 transcripts outnumber MinK transcripts five to one in human ventricles, suggesting KCNQ1 also forms other heteromeric or even homomeric channels there. Mechanisms governing which channel types prevail have… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 17 extracted citations


Publications referenced by this paper.
Showing 1-10 of 44 references

Similar Papers

Loading similar papers…