Mimics of the sialyl Lewis X tetrasaccharide. Replacement of the N-acetylglucosamine sugar with simple C2-symmetric 1,2-diols.

Abstract

Analogues of sialyl Lewis X have been synthesized that feature replacement of the N-acetylglucosamine residue with C2-symmetric diols. The diols used contain different levels of torsional constraint and various functional groups. The cyclohexyl derived compound 27 was equipotent to sLex in vitro (IC50 0.5 mM). 

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Cite this paper

@article{Prodger1996MimicsOT, title={Mimics of the sialyl Lewis X tetrasaccharide. Replacement of the N-acetylglucosamine sugar with simple C2-symmetric 1,2-diols.}, author={Jeremy C Prodger and Marion Bamford and Michael I Bird and Paul M Gore and David Holmes and Richard Priest and Victoria V{\'a}zquez S{\'a}ez}, journal={Bioorganic & medicinal chemistry}, year={1996}, volume={4 6}, pages={793-801} }