Mimicry of apoptotic cells by exposing phosphatidylserine participates in the establishment of amastigotes of Leishmania (L) amazonensis in mammalian hosts.

@article{Wanderley2006MimicryOA,
  title={Mimicry of apoptotic cells by exposing phosphatidylserine participates in the establishment of amastigotes of Leishmania (L) amazonensis in mammalian hosts.},
  author={J Wanderley and Maria Elisabete Costa Moreira and Aline Benjamin and Adriana Bonomo and Marcello Andr{\'e} Barcinski},
  journal={Journal of immunology},
  year={2006},
  volume={176 3},
  pages={1834-9}
}
Signaling through exposed phosphatidylserine (PS) is fundamental for the TGFbeta1-dependent, noninflammatory phagocytosis of apoptotic cells. This same mechanism operates in the internalization of amastigotes of Leishmania (L) amazonensis (L(L)a) in a process quoted as apoptotic mimicry. Now we show that the host modulates PS exposure by the amastigotes and, as a consequence, BALB/c mice-derived amastigotes expose significantly more PS than those derived from C57BL/6 mice. Due to this… CONTINUE READING

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