Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte-progenitor cells from cord blood.

@article{Deutsch2008MimickingTH,
  title={Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte-progenitor cells from cord blood.},
  author={Varda R Deutsch and Einav Hubel and Sigi Kay and Tal Ohayon and B. Katz and Ariel Many and A. G. Zander and Elizabeth Naparstek and David Grisaru},
  journal={British journal of haematology},
  year={2008},
  volume={149 1},
  pages={
          137-49
        }
}
Severe neutropenia and protracted thrombocytopenia remain serious clinical problems following cord blood transplantation (CBT) due to the paucity of stem and progenitor cells in the grafts. Administration of ex-vivo expanded megakaryocyte progenitor cells may facilitate platelet production. We propose a novel strategy to expand these rare cells ex-vivo, from a small portion of the cord blood (CB) unit, using fibronectin (FN), a major component of hematopoietic niches, combined with cytokines… CONTINUE READING
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