Mimicking nature: synthetic nicotinamide cofactors for C═C bioreduction using enoate reductases.

@article{Paul2013MimickingNS,
  title={Mimicking nature: synthetic nicotinamide cofactors for C═C bioreduction using enoate reductases.},
  author={Caroline E Paul and Serena Gargiulo and Diederik J Opperman and Iv{\'a}n Lavandera and Vicente Gotor-Fern{\'a}ndez and Vicente Gotor and Andreas Taglieber and Isabel W. C. E. Arends and Frank Hollmann},
  journal={Organic letters},
  year={2013},
  volume={15 1},
  pages={180-3}
}
A series of synthetic nicotinamide cofactors were synthesized to replace natural nicotinamide cofactors and promote enoate reductase (ER) catalyzed reactions without compromising the activity or stereoselectivity of the bioreduction process. Conversions and enantioselectivities of >99% were obtained for C═C bioreductions, and the process was successfully upscaled. Furthermore, high chemoselectivity was observed when employing these nicotinamide cofactor mimics (mNADs) with crude extracts in ER… CONTINUE READING

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