Mimicking microvascular alterations of human diabetic retinopathy: a challenge for the mouse models.

@article{Ramos2013MimickingMA,
  title={Mimicking microvascular alterations of human diabetic retinopathy: a challenge for the mouse models.},
  author={David Ramos and Ana G. Carretero and Marc Navarro and Lu{\'i}sa Mendes-Jorge and V{\'i}ctor Nacher and Alfonso Rodr{\'i}guez-Baeza and Jes{\'u}s Ruberte},
  journal={Current medicinal chemistry},
  year={2013},
  volume={20 26},
  pages={
          3200-17
        }
}
Although it has become acceptable that neuroretinal cells are also affected in diabetes, vascular lesions continue to be considered as the hallmarks of diabetic retinopathy. Animal models are essential for the understanding and treatment of human diabetic retinopathy, and the mouse is intensively used as a model because of its similarity to human and the possibility to be genetically modified. However, until today not all retinal vascular lesions developed in diabetic patients have been… CONTINUE READING