Mimicking live flavivirus immunization with a noninfectious RNA vaccine.

  title={Mimicking live flavivirus immunization with a noninfectious RNA vaccine.},
  author={Regina M. Kofler and Judith H Aberle and Stephan W. Aberle and Steven L. Allison and Franz X Heinz and Christian W. Mandl},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 7},
Flaviviruses are human pathogens of world-wide medical importance. They have recently received much additional attention because of their spread to new regions (such as West Nile virus to North America), highlighting their potential as newly emerging disease agents. Using tick-borne encephalitis virus, we have developed and evaluated in mice a new genetic vaccine based on self-replicating but noninfectious RNA. This RNA contains all of the necessary genetic information for establishing its… CONTINUE READING
31 Citations
1 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 31 extracted citations


Publications referenced by this paper.

www.pnas.org cgi doi

  • H. Ying, T. Z. Zaks, +5 authors N. P. Restifo
  • Nat. Med
  • 1999

Similar Papers

Loading similar papers…