Mimicking enzyme evolution by generating new (βα)8-barrels from (βα)4-half-barrels

@inproceedings{Hcker2004MimickingEE,
  title={Mimicking enzyme evolution by generating new (βα)8-barrels from (βα)4-half-barrels},
  author={Birte H{\"o}cker and J{\"o}rg Claren and Reinhard Sterner},
  year={2004}
}
Gene duplication and fusion events that multiply and link functional protein domains are crucial mechanisms of enzyme evolution. The analysis of amino acid sequences and three-dimensional structures suggested that the (βα)8-barrel, which is the most frequent fold among enzymes, has evolved by the duplication, fusion, and mixing of (βα)4-half-barrel domains. Here, we mimicked this evolutionary strategy by generating in vitro (βα)8-barrels from (βα)4-half-barrels that were deduced from the… CONTINUE READING

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