Millisecond-timescale, genetically targeted optical control of neural activity

@article{Boyden2005MillisecondtimescaleGT,
  title={Millisecond-timescale, genetically targeted optical control of neural activity},
  author={Edward S. Boyden and Feng Zhang and Ernst Bamberg and Georg Nagel and Karl Deisseroth},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={1263-1268}
}
Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demonstrate reliable, millisecond-timescale control of neuronal spiking, as well as control of excitatory… CONTINUE READING

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