Million-dollar Kavli prize recognizes scientist scooped on CRISPR

  title={Million-dollar Kavli prize recognizes scientist scooped on CRISPR},
  author={Giorgia Guglielmi},
Award goes to biochemists Virginijus Siksnys, whose lab independently developed the gene-editing tool, Emmanuelle Charpentier and Jennifer Doudna.Award goes to biochemists Virginijus Siksnys, whose lab independently developed the gene-editing tool, Emmanuelle Charpentier and Jennifer Doudna. 

Social Media and the Dissemination of Prepublication Data in Surgical Fields

In nonsurgical fields, the appropriateness of the use of social media to release prepublication data is increasingly being discussed and little guidance exists on how surgical conference attendees should use social media while at conferences.



RNA-Guided Human Genome Engineering via Cas9

The type II bacterial CRISPR system is engineer to function with custom guide RNA (gRNA) in human cells to establish an RNA-guided editing tool for facile, robust, and multiplexable human genome engineering.

Multiplex Genome Engineering Using CRISPR/Cas Systems

Two different type II CRISPR/Cas systems are engineered and it is demonstrated that Cas9 nucleases can be directed by short RNAs to induce precise cleavage at endogenous genomic loci in human and mouse cells, demonstrating easy programmability and wide applicability of the RNA-guided nuclease technology.

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.

Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

It is demonstrated that the Cas9–crRNA complex of the Streptococcus thermophilus CRISPR3/Cas system introduces in vitro a double-strand break at a specific site in DNA containing a sequence complementary to crRNA, paving the way for engineering of universal programmable RNA-guided DNA endonucleases.

Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.

The amplification mechanism primarily involves contractions of the outerhair cells, which are driven by changes in membrane potential and mediated by prestin, a motor protein in the outer hair cell lateral membrane, which sharpens the frequency resolution and augments sensitivity 100-fold around the cell's characteristic frequency.

This is a well-deserved prize for three individuals whose discovery made an enormous impact.” CORRECTION The Editorial ‘Smelting point

  • Compr. Physiol
  • 2018