Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation.

@article{Bergsten1990MillimolarCO,
  title={Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation.},
  author={Peter Bergsten and Gabriel Amitai and John H. Kehrl and Kuldeep R. Dhariwal and Harvey G Klein and Mark A Levine},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 5},
  pages={
          2584-7
        }
}
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177 Citations
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177 Citations

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Macrophage uptake and recycling of ascorbic acid: response to activation by lipopolysaccharide.

Role of ascorbic acid in transferrin-independent reduction and uptake of iron by U-937 cells.

Preferential uptake and accumulation of oxidized vitamin C by THP-1 monocytic cells.

The preferential uptake of the dehydro-form of the vitamin may be useful for situations where this short-lived metabolite is formed by oxidation in the environment.

Assessing the reductive capacity of cells by measuring the recycling of ascorbic and lipoic acids.

  • J. M. May
  • Biology
    Methods in molecular biology
  • 2010
Methods have been developed to assess the ability of intact cells to recycle ascorbate and to generate intracellular reducing equivalents required to maintain the redox status of the cells.

Vitamin C enters mouse T cells as dehydroascorbic acid in vitro and does not recapitulate in vivo vitamin C effects.

In vitro differentiation of human monocytes to macrophages results in depletion of antioxidants and increase in n‐3 fatty acids levels

Functions of vitamin C as a mediator of transmembrane electron transport in blood cells and related cell culture models.

The various pathways of regeneration of ascorbate and their relative contributions to the avoidance of vitamin loss in plasma or cell culture medium are discussed.
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