Milky spots promote ovarian cancer metastatic colonization of peritoneal adipose in experimental models.

@article{Clark2013MilkySP,
  title={Milky spots promote ovarian cancer metastatic colonization of peritoneal adipose in experimental models.},
  author={Robert J. Clark and Venkatesh Krishnan and Michael L Schoof and Irving Rodriguez and Betty R. Theriault and Marina A Chekmareva and Carrie W. Rinker-Schaeffer},
  journal={The American journal of pathology},
  year={2013},
  volume={183 2},
  pages={576-91}
}
The goal of controlling ovarian cancer metastasis formation has elicited considerable interest in identifying the tissue microenvironments involved in cancer cell colonization of the omentum. Omental adipose is a site of prodigious metastasis in both ovarian cancer models and clinical disease. This tissue is unusual for its milky spots, comprised of immune cells, stromal cells, and structural elements surrounding glomerulus-like capillary beds. The present study shows the novel finding that… CONTINUE READING
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