Milk thistle: Silybum marianum.

  title={Milk thistle: Silybum marianum.},
  author={Joseph Pepping},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  volume={56 12},
  • J. Pepping
  • Published 15 June 1999
  • Medicine
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Milk thistle is a well known and commonly used herb, used particularly in hepatic diseases. It has very potent antioxidant, anti-inflammatory, and antifibrotic properties (1). As a single agent its therapeutic effects in liver disease appear to be modest (2,3,4,5). Herbal medicines and supplements are likely to be much more beneficial when used synergistically in combinations or formulas. Milk thistle preparations have also shown promise in vitro in the treatment of malignancies. They have been… Expand
Milk Thistle (Silybum marianum) for the Therapy of Liver Disease
Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation, and to protect against genomic injury and stabilize mast cells, chelate iron, and slow calcium metabolism. Expand
Milk thistle has been used for 2,000 years as an herbal remedy for a variety of ailments, particularly liver, kidney, and gall bladder problems, and is beginning to be used to protect against nephrotoxicity as well. Expand
The Clinical Utility of Milk Thistle (Silybum marianum) in Cirrhosis of the Liver
Preliminary clinical evaluations of milk thistle for Cirrhosis of the liver indicate potential benefits in healthier patients with alcoholic cirrhosis, but major flaws in many of the studies make it difficult to draw solid conclusions. Expand
Silymarin and Its Role in Chronic Diseases.
In this present chapter, a comprehensive attempt has been made to discuss the potential of silymarin in chronic disorders. Expand
A review of Silybum marianum (milk thistle) as a treatment for alcoholic liver disease.
There are currently insufficient data from well-conducted clinical trials to recommend the use of Silybum marianum or its derivatives in patients with alcoholic liver disease. Expand
Milk Thistle Species ( Family ) Silybum marianum
  • 2010
Traditionally, milk thistle fruits have been used for disorders of the liver, spleen and gall bladder such as jaundice and gall bladder colic . Milk thistle has also been used for nursing mothers forExpand
Silymarin and its properties; a nephrology viewpoint
In this mini-review, the biological actions silymarin are reviewed. Milk thistle (Silybum marianum) is widely used in a traditional medicine. Silymarin, the active components of milk thistle,Expand
Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn.)
Clinical trials of milk thistle conducted in the past 5 years are reviewed including pharmacokinetic and toxicity studies, herb-drug interactions, and other safety issues, and toxic or adverse effects observed seem to be minimal. Expand
Drug Discovery from Mother Nature
Cinnamon (Cinnamomum zeylanicum and Cinnamon cassia), the eternal tree of tropical medicine, belongs to the Lauraceae family and is one of the most important spices used daily by people all over theExpand
Introduction Silybum marianum, also known as Milk Thistle, Blessed Thistle, Medit erranean Thistle or Scotch Thistle, is a commonly prescribed herbal remedy in the UK. It has red or purple petals,Expand


Silibinin protects against cisplatin-induced nephrotoxicity without compromising cisplatin or ifosfamide anti-tumour activity.
In vitro data rule out a significant inhibition of the anti-tumour activity of the major nephrotoxic components, cisplatin and 4-hydroperoxy-ifosfamide, by co-administration of silibinin in a human germ cell tumour cell line model. Expand
Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial.
The results of this study indicate that silymarin has no effect on survival and the clinical course in alcoholics with liver cirrhosis. Expand
Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients.
The data indicate that the bioavailability of silybin is much greater after administration of silipide than afteradministering silymarin, which results in increased delivery of the compound to the liver, which represents the target organ for pharmacological action. Expand