Milk thistle: Silybum marianum.

@article{Pepping1999MilkTS,
  title={Milk thistle: Silybum marianum.},
  author={Joseph Pepping},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  year={1999},
  volume={56 12},
  pages={
          1195-7
        }
}
  • J. Pepping
  • Published 15 June 1999
  • Medicine
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Milk thistle is a well known and commonly used herb, used particularly in hepatic diseases. It has very potent antioxidant, anti-inflammatory, and antifibrotic properties (1). As a single agent its therapeutic effects in liver disease appear to be modest (2,3,4,5). Herbal medicines and supplements are likely to be much more beneficial when used synergistically in combinations or formulas. Milk thistle preparations have also shown promise in vitro in the treatment of malignancies. They have been… Expand
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Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients.
TLDR
The data indicate that the bioavailability of silybin is much greater after administration of silipide than afteradministering silymarin, which results in increased delivery of the compound to the liver, which represents the target organ for pharmacological action. Expand