Milk allergy/intolerance and atopic dermatitis in infancy and childhood

  title={Milk allergy/intolerance and atopic dermatitis in infancy and childhood},
  author={Elio Novembre and Alberto Vierucci},
Adverse reactions to cow’s milk proteins are usually indicated as cow’s milk allergy/intolerance (CMPA/CMPI) because no differentiation is possible on the basis of symptoms, and there is no reliable single laboratory test available for the diagnosis of CMPA or CMPI. Elimination and challenge tests for cow’s milk proteins using strict, well‐defined diagnostic criteria are required for the diagnosis of CMPA/CMPI. Atopic dermatitis (AD) is one of the most common symptoms of CMPA/CMPI… 

The Role of Cow Milk Allergy in Increasing the Severity of Atopic Dermatitis

The severity of atopic dermatitis in patients with CMA was significantly higher than patients without CMA and the important role of CM allergen proteins in the induction and in increasing the severity of AD in children is shown.

Natural course of cow's milk allergy in childhood atopic eczema/dermatitis syndrome.

Persistence of cow's milk allergy beyond two years of age.

Unnecessary Milk Elimination Diets in Children with Atopic Dermatitis

An actual prevalence of cow's milk allergy in patients on milk elimination diets is demonstrated to be significantly lower than the number of patients prescribed such diets (24.2%)—confirming that this measure is being applied excessively.


A practical approach for the diagnosis and management of suspected cow’s milk protein allergy according to age and symptom severity is presented.

Efficacy and Safety of Soy Protein Based Formula in Atopic Dermatitis

It is suggested that SPF could be useful in decreasing the severity of AD without affecting infant growth status and could provide an adequate and safe alternative to hCMF in treating infants with AD and CMA during the first 12 to 24 months of their life.

Towards better triage of infants suspected of cow's milk allergy: development of a preliminary multivariable diagnostic index

It is concluded that a diagnostic model with three clinical parameters may be used for better referral of children suspected of CMA and the decision to either initially perform an open food challenge or directly perform a DBPCFC is made.

Component-specific immunoglobulin E in the diagnosis of allergic disease in childhood: more of the same or something more?

The aim of this review is to familiarize the reader with the state of the art in component- and epitope-specific diagnosis in allergic disease in childhood, as well as future prospects for novel therapeutic approaches incorporating these data.

Health Economics and Nutrition : Atopic Dermatitis

It is proposed that allergy is rather a consequence of AD in subjects with a concomitant underlying atopic constitution, and the strongest association so far with the gene encoding filaggrin has raised the recent interest in the role of skin barrier impairment in the development of AD.



Cow's milk protein allergy and intolerance in infancy Some clinical, epidemiological and immunological aspects

  • A. Høst
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 1994
The degree of antibody response to CMP exposure is a better predictor of persisting CMPA than a single finding of an elevated antibody level which can occur in normal infants without CMPA/CMPI.

Epidemiology and prevention of cow's milk allerw

No single laboratory test is diagnostic of CMPNCMPI, and differentiation between CMPA and CMPI cannot be based solely on clinical symptoms, so the diagnosis has to be based on strict, well-defined elimination and milk challenge procedures.

Cow milk allergy within the spectrum of atopic disorders

Children with IgE mediated CMA frequently generate IgE responses to multiple dietary and inhalant allergens in infancy and early childhood and develop immediate hypersensitivity to other foods as well as clinical eczema, and asthma.

Clinical manifestations of cows’ milk allergy in childhood. II. The diagnostic value of skin tests and RAST

In a study of cows’ milk allergy (CMA) in infancy, 135 consecutive challenges were performed on children with a good clinical history of the disorder, it was shown that all patients with SPT 4 had CMA.

Manifestations of milk allergy in infancy: clinical and immunologic findings.

Development of allergic disorders in children with cow's milk protein allergy or intolerance in infancy

The diagnosis CMPA/CMPI is made according to criteria proposed by Savilahti, Bahna and Gandhi, and taken over by the European Society for Paediatric Gastroenterology and Nutrition Working Group for the diagnostic criteria for food Allergy.

Food hypersensitivity and atopic dermatitis: pathophysiology, epidemiology, diagnosis, and management.

Reliability of tests for specific IgE to food in atopic dermatitis *

The experience in diagnosing food allergy in children with AD is reported, which shows that the pediatrician treating a child with AD often experiences several difficulties in detecting the offending food(s).

Immunologic changes associated with the development of tolerance in children with cow milk allergy.