Milieu of Diabetes in the 2nd Decade of 21st Century

  title={Milieu of Diabetes in the 2nd Decade of 21st Century},
  author={Shilpa Suneja and Yvonne Christian and Nimai Chand Chandra},
  journal={Journal of diabetes \& metabolism},
Diabetes mellitus, a multifactorial pathology, is a growing health problem in developed and developing countries of the modern world. Genetic, ethnic, health, dietary habit, sedentary potential, gestational abnormality in addition to other environmental stress factors are the potential stimuli for precipitating diabetic patho-physiology. The chemistry of diabetes and its milieu are multi-directional and cross-connectable. Diabetes is inter-related to hypertension, obesity, atherosclerosis… 

Diabetes, Obesity and Atherosclerosis: Three Buds of One Stem MS-X

  • N. Chandra
  • Biology
    Interventions in Obesity & Diabetes
  • 2019
It is shown that obesity reduces tyrosine phosphorylation of insulin receptor and hence initiates insulin resistance and an association of insulin and LDL receptors and this association keeps LDL receptor non-functional making the system prone to vessel LDL accumulation.

Atherosclerosis and carcinoma: Two facets of dysfunctional cholesterol homeostasis

  • N. Chandra
  • Medicine, Biology
    Journal of biochemical and molecular toxicology
  • 2020
Cholesterol is now a global target for maintaining quality health, particularly to control the two giants of the present world health tragedy: atherosclerosis and carcinoma, which appear to be the two facets of dysfunctional cholesterol homeostasis.

Quality of Genom in Type II Diabetes Mellitus Patients in Viewed of Temperature, Storage Duration, Number of Leukocyte

Type II Diabetes Mellitus is a disorder caused by genetic and environmental factors. Molecular analysis of T2DM abnormalities has been carried out. But the analysis in sample preparation especially

A comprehensive account of insulin and LDL receptor activity over the years: A highlight on their signaling and functional role

  • N. Chandra
  • Biology, Medicine
    Journal of biochemical and molecular toxicology
  • 2021
RD was found to mimic IR-generated signaling path when it remains bound to IR in IR-DLR interlocked state, the first time LDLR was found sending messages besides its LDL-clearing activity from blood vessels.

Low Density Lipoproteinemia in Obese and Type-2 Diabetics from Association of IR and LDLR

Universality of association of two receptors, LDLR (LDL receptor) and IR (insulin receptor), has been explored in various cell types and intracellular compartments including caveolae vesicles in plasma membrane to prove the existence of association in type-2 diabetes and diabetes associated obesity.



The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

Over the past three decades, the number of people with diabetes mellitus has more than doubled globally, making it one of the most important public health challenges to all nations. Type 2 diabetes

Diabetes mellitus as a risk factor for cancer: stress or viral etiology?

This review considers both stress and viral infections as possible etiology of cancer in diabetes.

Early Life Factors and Type 2 Diabetes Mellitus

It might be possible to prevent or delay the risk for type 2 diabetes mellitus by improving pre- and/or postnatal factors, and the potential mechanisms that may underlie the developmental programming of T2DM are addressed.

[Stress-induced hypertension and diabetes mellitus].

New associations are sought which will enable the mutual relationship of hypertension, metabolic disorders and cardiovascular disease to be described more satisfactorily.

Regenerative medicine of the pancreatic beta cells.

The regenerative processes of the pancreas observed in animal models in vivo, and approaches to promote the regeneration of the Pancreas in vivo are summarized and considered for the cure of diabetes in the future.

Epigenetic changes in diabetes

Epigenetic mechanisms impact gene expression that could predispose individuals to the diabetic phenotype during intrauterine and early postnatal development, as well as throughout adult life, and Understanding the molecular events that underlie these transcriptional changes will significantly contribute to novel therapeutic interventions to prevent, reverse or retard the deleterious effects of the diabetic milieu.

Dyslipoproteinemias in diabetes.

  • G. Steiner
  • Medicine
    Clinical and investigative medicine. Medecine clinique et experimentale
  • 1995

Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer.

The use of insulin sensitizers in parallel with forthcoming FASN inhibitors should be a valuable therapeutic approach that, in association with lifestyle interventions, would concurrently improve energy-flux status, ameliorate insulin sensitivity, and alleviate the risk of lipogenic carcinomas.