Milestones in PD genetics.

  title={Milestones in PD genetics.},
  author={Thomas Gasser and John S. Hardy and Yoshikuni Mizuno},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  volume={26 6},
Over the last 25 years, genetic findings have profoundly changed our views on the etiology of Parkinson's disease. Linkage studies and positional cloning strategies have identified mutations in a number of genes that cause several monogenic autosomal-dominant or autosomal-recessive forms of the disorder. Although most of these Mendelian forms of Parkinson's disease are rare, whole-genome association studies have more recently provided convincing evidence that low-penetrance variants in at least… CONTINUE READING

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