Mildronate exerts acute anticonvulsant and antihypnotic effects

  title={Mildronate exerts acute anticonvulsant and antihypnotic effects},
  author={L. Zvejniece and B. {\vS}valbe and Marina Makrecka and E. Liepinsh and I. Kalvinsh and M. Dambrova},
  journal={Behavioural Pharmacology},
  • L. Zvejniece, B. Švalbe, +3 authors M. Dambrova
  • Published 2010
  • Chemistry, Medicine
  • Behavioural Pharmacology
  • The effects of mildronate [3-(2,2,2-trimethylhydrazinium) propionate], an inhibitor of L-carnitine biosynthesis and an anti-ischaemic drug, were examined in various in-vivo conditions to investigate the neuropharmacological profile after acute administration. Mildronate (200 mg/kg, acute intraperitoneal administration) exerted anticonvulsant activity in a chemoconvulsant pentylenetetrazole-induced clonic and tonic seizure test but did not change the effects of a convulsion-inducing dose of… CONTINUE READING
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