Mild to Moderate Muscular Symptoms with High-Dosage Statin Therapy in Hyperlipidemic Patients —The PRIMO Study
@article{Bruckert2005MildTM, title={Mild to Moderate Muscular Symptoms with High-Dosage Statin Therapy in Hyperlipidemic Patients —The PRIMO Study}, author={Eric Bruckert and Gilles Hayem and Sylvie Dejager and Caroline Yau and Bernard B{\'e}gaud}, journal={Cardiovascular Drugs and Therapy}, year={2005}, volume={19}, pages={403-414} }
SummaryObjectives: To characterize the risk factors, rate of occurrence, onset, nature and impact of mild to moderate muscular symptoms with high-dosage HMG-CoA reductase inhibitor (statin) therapy in general practice.Methods: The Prédiction du Risque Musculaire en Observationnel (Prediction of Muscular Risk in Observational conditions, PRIMO) survey was an observational study of muscular symptoms in an unselected population of 7924 hyperlipidemic patients receiving high-dosage statin therapy…
1,097 Citations
Statin-Associated Muscle Symptoms: SAM
- Medicine
- 2018
The epidemiology, the mechanism of action, and the management options for SAM include statin switching (to low dose or more hydrophilic), hold or discontinuation and/or need for additional therapy.
CHALLENGING CLINICAL ISSUE OF MUSCLE SYMPTOMS IN STATIN TREATED PATIENTS: A COMPARISON WITH AHA GUIDELINES
- Medicine
- 2017
There is strong evidence that statin lead to frequent muscle related adverse effects and may be challenging in some patientseven at lower doses than the recommendation of American Heart Association.
Discontinuation of statin therapy due to muscular side effects: a survey in real life.
- MedicineNutrition, metabolism, and cardiovascular diseases : NMCD
- 2013
An insight into statin use and its association with muscular side effects in clinical practice
- Medicine, PsychologyRomanian journal of internal medicine = Revue roumaine de medecine interne
- 2015
In the studied set of patients muscular symptoms were a rather frequent effect of statin therapy, and could lead to more severe outcomes, their timely detection and management is important.
Statin-induced myopathy in a usual care setting—a prospective observational study of gender differences
- Medicine, PsychologyEuropean Journal of Clinical Pharmacology
- 2016
Women reported a higher frequency of myopathy and other ADRs as well as a larger impact on daily life activities as compared to men, which raises the question about common underlying mechanisms of statin-induced myopathy.
Severity of statin-induced adverse effects on muscle and associated conditions: data from the DAMA study
- MedicineExpert opinion on drug safety
- 2016
Myalgia was the most common muscle adverse effect associated with statin therapy, and excessive alcohol consumption and pravastatin therapy were independently associated with myositis or rhabdomyolysis.
Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy
- Medicine, BiologyInternational journal of molecular sciences
- 2021
A high number of risk factors may increase the probability of myotoxicity induced by statin therapy, and some of these, related to pharmacokinetic properties of statins and to concomitant therapies or patient characteristics, may affect statin bioavailability and increase vulnerability to high-dose statins.
Factors associated with statin-related adverse muscular events in adult dyslipidemic outpatients
- Medicine, Biology
- 2018
The results are suggestive that the type of statin prescribed and the concomitant use of ABCB1 inhibitors increase the susceptibility to adverse muscular events during statin therapy in dyslipidemic outpatients.
Treatment Options for Statin-Associated Muscle Symptoms.
- MedicineDeutsches Arzteblatt international
- 2015
SAMS are important adverse effects of statin treatment because they lessen drug adherence and patients with SAMS should undergo a thorough diagnostic evaluation followed by appropriate counseling.
References
SHOWING 1-10 OF 43 REFERENCES
A Comprehensive Description of Muscle Symptoms Associated with Lipid-Lowering Drugs
- MedicineCardiovascular Drugs and Therapy
- 2004
The role and importance of a genetic background predisposing to low-grade myopathy deserves further investigation, and the impact of these mild symptoms on daily activities might not be negligible in a subset of patients.
Can Statins Cause Chronic Low-Grade Myopathy?
- MedicineAnnals of Internal Medicine
- 2002
Four patients who had muscle symptoms during statin therapy that resolved during placebo use were suggested to have statin-associated myopathy with normal serum creatine kinase levels, a novel approach that used quantitative measures of muscle strength and muscle biopsy to address the question of myopathy in patients in whom muscle symptoms are closely correlated with statin use.
Risk for myopathy with statin therapy in high-risk patients.
- Medicine, BiologyArchives of internal medicine
- 2003
Clinicians should be alert to the potential for drug-drug interactions to minimize the risk of myopathy during long-term statin therapy in patients at high risk for coronary heart disease.
Muscular Side Effects of Statins
- MedicineJournal of cardiovascular pharmacology
- 2002
The data indicate that severe muscular side effects are rare and much more research should be directed onto the pathophysiological (genetic?) background to finally evaluate possible therapeutic consequences rather than simply to withdraw or change the respective statin.
Compliance with fluvastatin treatment characterization of the noncompliant population within a population of 3845 patients with hyperlipidemia. CREOLE Study Team.
- MedicineJournal of clinical epidemiology
- 1999
Frequency of creatine kinase elevation during treatment with fluvastatin.
- MedicineThe American journal of cardiology
- 2002
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial
- MedicineThe Lancet
- 2002
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
- MedicineThe Lancet
- 1994
Rhabdomyolysis and HMG-CoA Reductase Inhibitors
- Medicine, BiologyThe Annals of pharmacotherapy
- 2001
Rhabdomyolysis is a rare but clinically important adverse event of statin monotherapy or combination therapy and thorough understanding of this condition may help prevent or minimize adverse health outcomes in patients receiving statin therapy.
Adherence with statin therapy in elderly patients with and without acute coronary syndromes.
- Medicine, Political ScienceJAMA
- 2002