Mild to Moderate Muscular Symptoms with High-Dosage Statin Therapy in Hyperlipidemic Patients —The PRIMO Study

  title={Mild to Moderate Muscular Symptoms with High-Dosage Statin Therapy in Hyperlipidemic Patients —The PRIMO Study},
  author={E. Bruckert and G. Hayem and S. Dejager and C. Yau and B. B{\'e}gaud},
  journal={Cardiovascular Drugs and Therapy},
  • E. Bruckert, G. Hayem, +2 authors B. Bégaud
  • Published 2005
  • Medicine
  • Cardiovascular Drugs and Therapy
  • SummaryObjectives: To characterize the risk factors, rate of occurrence, onset, nature and impact of mild to moderate muscular symptoms with high-dosage HMG-CoA reductase inhibitor (statin) therapy in general practice.Methods: The Prédiction du Risque Musculaire en Observationnel (Prediction of Muscular Risk in Observational conditions, PRIMO) survey was an observational study of muscular symptoms in an unselected population of 7924 hyperlipidemic patients receiving high-dosage statin therapy… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Paper Mentions

    The purpose of this study is to investigate the mechanism of statin-related myopathy by evaluating muscle samples before and after statin exposure.  
    ConditionsHydroxymethylglutaryl-CoA Reductase Inhibitors, Myopathy
    An insight into statin use and its association with muscular side effects in clinical practice
    • 3
    • Highly Influenced
    • PDF
    Intolerance to Statins: Mechanisms and Management
    • 93
    • Highly Influenced
    • PDF


    Publications referenced by this paper.
    A Comprehensive Description of Muscle Symptoms Associated with Lipid-Lowering Drugs
    • 102
    Can Statins Cause Chronic Low-Grade Myopathy?
    • 56
    Risk for myopathy with statin therapy in high-risk patients.
    • 442
    • Highly Influential
    • PDF
    Muscular Side Effects of Statins
    • 119
    Rhabdomyolysis and HMG-CoA Reductase Inhibitors
    • 317
    Adherence with statin therapy in elderly patients with and without acute coronary syndromes.
    • 683
    • PDF