Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release.

@article{Zhao2004MildPH,
  title={Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release.},
  author={Heng Zhao and Midori A Yenari and Robert Morris Sapolsky and G K Steinberg},
  journal={Stroke},
  year={2004},
  volume={35 2},
  pages={572-7}
}
BACKGROUND AND PURPOSE We showed previously that Bcl-2 overexpression with the use of herpes simplex viral (HSV) vectors improved striatal neuron survival when delivered 1.5 hours after stroke but not when delivered 5 hours after stroke onset. Here we determine whether hypothermia prolongs the therapeutic window for gene therapy. METHODS Rats were subjected to focal ischemia for 1 hour. Hypothermia (33 degrees C) was induced 2 hours after insult and maintained for 3 hours. Five hours after… CONTINUE READING

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