Mild hypoxia impairs alveolarization in the endothelial nitric oxide synthase-deficient mouse.

@article{Balasubramaniam2003MildHI,
  title={Mild hypoxia impairs alveolarization in the endothelial nitric oxide synthase-deficient mouse.},
  author={V. M. Bala Balasubramaniam and Jessica Tang and Anne M Maxey and Charles G. Plopper and Steven H Abman},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={284 6},
  pages={
          L964-71
        }
}
In addition to its vasodilator properties, nitric oxide (NO) promotes angiogenesis in the systemic circulation and tumors. However, the role of NO in promoting normal lung vascular growth and its impact on alveolarization during development or in response to perinatal stress is unknown. We hypothesized that NO modulates lung vascular and alveolar growth and that decreased NO production impairs distal lung growth in response to mild hypoxia. Litters of 1-day-old mouse pups from parents that were… CONTINUE READING

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