Mild hypothermia to limit myocardial ischemia-reperfusion injury: importance of timing.

  title={Mild hypothermia to limit myocardial ischemia-reperfusion injury: importance of timing.},
  author={Shinya Kanemoto and Muneaki Matsubara and Mio Noma and Bradley G. Leshnower and Landi M Parish and Benjamin M. Jackson and Robin H. Hinmon and Hirotsugu Hamamoto and Joseph H. Gorman and Robert C. Gorman},
  journal={The Annals of thoracic surgery},
  volume={87 1},
BACKGROUND Hypothermia during ischemia has been shown to reduce myocardial reperfusion injury. We sought to establish the cardioprotective effect of very mild total-body hypothermia (<or= 2.5 degrees C) and to determine whether the application of hypothermia at different points during the ischemia-reperfusion period influenced the degree of myocardial salvage. METHODS Rabbits were subjected to 30 minutes of myocardial ischemia followed by 3 hours of reperfusion. Twenty-five animals were… CONTINUE READING


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Myocardial reperfusion injury.

The New England journal of medicine • 2007
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