Mild hypothermia inhibits systemic and cerebral complement activation in a swine model of cardiac arrest.

@article{Gong2015MildHI,
  title={Mild hypothermia inhibits systemic and cerebral complement activation in a swine model of cardiac arrest.},
  author={Ping Gong and Hong Zhao and Rong Hua and Mingyue Zhang and Ziren Tang and Xue Mei and Juan Cui and Chunsheng Li},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2015},
  volume={35 8},
  pages={1289-95}
}
Complement activation has been implicated in ischemia/reperfusion injury. This study aimed to determine whether mild hypothermia (HT) inhibits systemic and cerebral complement activation after resuscitation from cardiac arrest. Sixteen minipigs resuscitated from 8 minutes of untreated ventricular fibrillation were randomized into two groups: HT group (n=8), treated with HT (33°C) for 12 hours; and normothermia group (n=8), treated similarly as HT group except for cooling. Blood samples were… CONTINUE READING