Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.

@article{Empey2012MildHD,
  title={Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.},
  author={Philip E. Empey and Tricia M. Miller and Ashley H Philbrick and John A Melick and Patrick M Kochanek and Samuel M. Poloyac},
  journal={Critical care medicine},
  year={2012},
  volume={40 4},
  pages={1221-8}
}
OBJECTIVES Therapeutic hypothermia is widely employed for neuroprotection after cardiac arrest. However, concern regarding elevated drug concentrations during hypothermia and increased adverse drug reaction risk complicates concurrent pharmacotherapy. Many commonly used medications in critically ill patients rely on the cytochrome P450 3A isoform for their… CONTINUE READING