Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke.

@article{Yenari2002MildHA,
  title={Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke.},
  author={Midori A Yenari and Satoshi Iwayama and Danye Cheng and Guo Hua Sun and M Fujimura and Yuiko Morita-Fujimura and Pak Hoo Chan and G K Steinberg},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2002},
  volume={22 1},
  pages={
          29-38
        }
}
Mild hypothermia protects the brain from ischemia, but the underlying mechanisms of this effect are not well known. The authors previously found that hypothermia reduces the density of apoptotic cells, but it is not certain whether temperature alters associated biochemical events. Mitochondrial release of cytochrome c has recently been shown to be a key trigger in caspase activation and apoptosis via the intrinsic pathway. Using a model of transient focal cerebral ischemia, the authors… CONTINUE READING
Highly Cited
This paper has 94 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2005
View 10 Excerpts
Method Support
Highly Influenced

FasL shedding is reduced by hypothermia in experimental stroke.

Journal of neurochemistry • 2008
View 4 Excerpts
Method Support
Highly Influenced

94 Citations

0510'03'06'10'14'18
Citations per Year
Semantic Scholar estimates that this publication has 94 citations based on the available data.

See our FAQ for additional information.