Mild hyperthermia with magnetic resonance-guided high-intensity focused ultrasound for applications in drug delivery.

@article{Partanen2012MildHW,
  title={Mild hyperthermia with magnetic resonance-guided high-intensity focused ultrasound for applications in drug delivery.},
  author={Ari Ilkka Mikael Partanen and Pavel S. Yarmolenko and Antti Viitala and Sunil Appanaboyina and Dieter Haemmerich and Ashish Ranjan and Genevieve Jacobs and David L Woods and Julia K. Enholm and Bradford J. Wood and Matthew R. Dreher},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  year={2012},
  volume={28 4},
  pages={320-36}
}
PURPOSE Mild hyperthermia (40-45 °C) is a proven adjuvant for radiotherapy and chemotherapy. Magnetic resonance guided high intensity focused ultrasound (MR-HIFU) can non-invasively heat solid tumours under image guidance. Low temperature-sensitive liposomes (LTSLs) release their drug cargo in response to heat (>40 °C) and may improve drug delivery to solid tumours when combined with mild hyperthermia. The objective of this study was to develop and implement a clinically relevant MR-HIFU mild… CONTINUE READING
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