Mild generation of 5-(2'-deoxyuridinyl)methyl radical from a phenyl selenide precursor.

Abstract

[reaction: see text] 5-(2'-Deoxyuridinyl)methyl radical (1) resulting from formal hydrogen atom abstraction from the methyl group of thymidine is produced from the respective phenyl selenide precursor (2) via 350 nm photolysis or mild thermolysis (37 degrees C in the presence of glutathione) under aerobic or anaerobic conditions. The mild thermal generation… (More)

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