Mild fluorination of chloropyridines with in situ generated anhydrous tetrabutylammonium fluoride.


This paper describes the fluorination of nitrogen heterocycles using anhydrous NBu4F. Quinoline derivatives as well as a number of 3- and 5-substituted pyridines undergo high-yielding fluorination at room temperature using this reagent. These results with anhydrous NBu4F compare favorably to traditional halex fluorinations using alkali metal fluorides… (More)
DOI: 10.1021/jo5003054


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