Mild experimental autoimmune encephalitis as a tool to induce blood–brain barrier dysfunction

@article{Boettger2009MildEA,
  title={Mild experimental autoimmune encephalitis as a tool to induce blood–brain barrier dysfunction},
  author={Michael K Boettger and Andreas Weishaupt and Christian Geis and Klaus Viktor Toyka and Claudia Sommer},
  journal={Journal of Neural Transmission},
  year={2009},
  volume={117},
  pages={165-169}
}
The blood–brain barrier (BBB) serves as a border limiting access of immunoglobulins from the circulation into the brain. This becomes relevant when studying the pathogenesis of antibody-mediated autoimmune CNS disorders. Here, we characterized the BBB dysfunction in a model of mild experimental adoptive transfer autoimmune encephalomyelitis (AT-EAE). We show that large molecules can readily penetrate the BBB between days 3 and 7 after EAE-induction. This model may be valuable for studying… CONTINUE READING

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Separation methods that are capable of revealing blood-brain barrier permeability.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences • 2003
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