Mild cognitive impairment as a diagnostic entity

@article{Petersen2004MildCI,
  title={Mild cognitive impairment as a diagnostic entity},
  author={Ronald C. Petersen},
  journal={Journal of Internal Medicine},
  year={2004},
  volume={256}
}
  • R. Petersen
  • Published 1 September 2004
  • Psychology, Medicine, Biology
  • Journal of Internal Medicine
The concept of cognitive impairment intervening between normal ageing and very early dementia has been in the literature for many years. Recently, the construct of mild cognitive impairment (MCI) has been proposed to designate an early, but abnormal, state of cognitive impairment. MCI has generated a great deal of research from both clinical and research perspectives. Numerous epidemiological studies have documented the accelerated rate of progression to dementia and Alzheimer's disease (AD) in… 

Mild Cognitive Impairment: An Overview

TLDR
An algorithm is presented to assist the clinician in identifying subjects and subclassifying them into the various types of MCI, and directions for future research are proposed.

Mild Cognitive Impairment

  • O. Lopez
  • Medicine, Psychology
    Continuum
  • 2013
TLDR
The evolution of the clinical concept of MCI, the operationalization of its current definitions, the development of biomarkers that can help to identify an underlying neurodegenerative process as the etiology of the syndrome, and its proposed treatments are presented.

Mild cognitive impairment

TLDR
Results from several randomized clinical trials have been completed recently, and although most are essentially negative, one trial suggested that donepezil might be effective for the treatment of MCI for a limited period of time.

Diagnosing Mild Cognitive Impairment as a Precursor to Dementia: Fact or Fallacy?

Mild cognitive impairment (MCI) describes a period of subclinical cognitive decline associated with an increased risk for the development of Alzheimer's disease (AD). However, research groups have

Mild cognitive impairment: Believe it or not?

TLDR
The objective of this review will be to consider the question of whether MCI is a well enough established entity that it can be a diagnosis in medical practice and a valid target of Alzheimer's prevention therapy.

Mild Cognitive Impairment.

TLDR
MCI is an important clinical entity to identify, and while uncertainties persist, clinicians need to be aware of its diagnostic features to enable them to counsel patients.

Mild Cognitive Impairment: Diagnosis, Longitudinal Course, and Emerging Treatments

TLDR
A brief overview of the evolution of the concept of MCI is provided and current diagnostic criteria, the longitudinal course of the disorder, and current and emerging treatments for MCI are reviewed.

Mild Cognitive Impairment

TLDR
Mild Cognitive Impairment is a disease between normal cognitive ageing and dementia, and the continual development of pharmacologic approaches to modify and delay the natural history of progression of the disease motivates a great interest in an earlier diagnosis.

From mild cognitive impairment to subjective cognitive decline: conceptual and methodological evolution

TLDR
Several clinical and biomarker features were proposed to predict risk of conversion to AD in subjects with SCD and further longitudinal studies are needed to support the validity of these high-risk features.

Early diagnosis of Alzheimer's disease: is MCI too late?

  • R. Petersen
  • Psychology, Medicine
    Current Alzheimer research
  • 2009
TLDR
The construct of mild cognitive impairment (MCI) has come to represent an intermediate clinical state between the cognitive changes of aging and the very earliest features of Alzheimer's disease.
...

References

SHOWING 1-10 OF 49 REFERENCES

Current concepts in mild cognitive impairment.

TLDR
A group of experts on aging and MCI from around the world in the fields of neurology, psychiatry, geriatrics, neuropsychology, neuroimaging, neuropathology, clinical trials, and ethics was convened to summarize the current state of the field of MCI.

Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials.

TLDR
Patients with MCI had a predominant memory impairment with relative sparing of other cognitive domains and were intermediate between clinically normal individuals and patients with AD on cognitive and functional ratings.

Classification criteria for mild cognitive impairment: A population-based validation study

TLDR
MCI criteria perform poorly when applied to a representative population sample, and the authors propose modifications to current diagnostic criteria to increase their capacity to detect incipient dementia.

Mild cognitive impairment: clinical characterization and outcome.

TLDR
Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions.

Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment

TLDR
In older patients with MCI, hippocampal atrophy determined by premorbid MRI-based volume measurements is predictive of subsequent conversion to AD.

Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals.

TLDR
Patients with mild cognitive impairment can be clinically defined, many members of this group progress to Alzheimer's disease, and APOE epsilon 4 allele status appears to be a strong predictor of clinical progression.

Mild cognitive impairment clinical trials

  • R. Petersen
  • Psychology, Biology
    Nature Reviews Drug Discovery
  • 2003
TLDR
The concept of secondary prevention treatment trials involving minimally symptomatic individuals, such as persons with mild cognitive impairment (MCI) — a transitional stage between normal ageing and very early Alzheimer's disease — has evolved and seems more promising.

Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1.

TLDR
The prevalence of mild cognitive impairment and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study was determined, and specific subtypes of MCI were examined in detail only at the Pittsburgh, Pa, center.

Clinical-neuropathological correlations in Alzheimer's disease and related dementias.

TLDR
Clinicians accurately predicted AD pathological findings or their absence in most cases, but Attributing other degenerative dementias to AD, misdiagnosing patients with combined AD and Lewy bodies and misjudging the vascular contribution to dementia were the major areas of inaccuracy.

Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review)

TLDR
Screening different groups of elderly individuals in a general or specialty practice would be beneficial in detecting dementia and persons with memory impairment who were not demented were characterized in the literature as having mild cognitive impairment.