Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF iron.

@article{Lavados2008MildCI,
  title={Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF iron.},
  author={Manuel Lavados and Marta Guill{\'o}n and Mar{\'i}a Cristina Mujica and Leonel E. Rojo and Patricio Fuentes and Ricardo Benjamin Maccioni},
  journal={Journal of Alzheimer's disease : JAD},
  year={2008},
  volume={13 2},
  pages={225-32}
}
Oxidative stress constitutes a hallmark of Alzheimer's disease (AD). Recent studies also point to redox active metals such as iron, copper and zinc in mediating oxidative stress in AD pathogenesis. However, the reactivity of cerebrospinal fluid (CSF) iron and its possible correlation with the severity of cognitive decline in both Alzheimer's patients and subjects with mild cognitive impairment (MCI) is still unknown. Here we show that different stages of cognitive and functional impairment are… CONTINUE READING
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