Mild cognitive impairment

@article{Chtelat2003MildCI,
  title={Mild cognitive impairment},
  author={G. Ch{\'e}telat and B. Desgranges and V. de la Sayette and F. Viader and F. Eustache and J. Baron},
  journal={Neurology},
  year={2003},
  volume={60},
  pages={1374 - 1377}
}
Patients with mild cognitive impairment (MCI) were assessed, and a metabolic profile associated with conversion to AD at 18-month follow-up was sought. As compared with nonconverters (n = 10), converters (n = 7) had lower fluorodeoxyglucose uptake in the right temporoparietal cortex (p = 0.02, corrected for cluster size), without individual overlap. Awaiting replication in an independent sample, these findings suggest that among patients with MCI, fluorodeoxyglucose PET may accurately identify… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
TLDR
Logistic regression indicated the two variables that most effectively predicted future development of AD were rCMRGlu from the left temporoparietal area and performance on the block design and these combined measures gave an optimal 90% correct classification rate. Expand
Age related cognitive decline: a clinical entity? A longitudinal study of cerebral blood flow and memory performance.
TLDR
Evaluating the changes in regional cerebral blood flow (rCBF) and memory performance in patients with age related cognitive decline who did and did not become demented during a follow up period found non-demented patients who have brain dysfunction that may represent a distinct clinical entity. Expand
The neural substrates of episodic memory impairment in Alzheimer's disease as revealed by FDG-PET: relationship to degree of deterioration.
TLDR
These findings suggest that, when episodic memory is mildly impaired, limbic functions are still sufficient to subserve the remaining performance, whereas with more severe memory deficit resulting from accumulated pathology the neocortical areas that are normally involved in semantic memory are recruited, perhaps as a form of (inadequate) compensatory mechanism. Expand
Preclinical prediction of Alzheimer's disease using SPECT
TLDR
Three of the four brain regions important for discriminating Converters from normal controls involve a distributed brain network pertaining to memory, suggesting that this network may be selectively affected in the earliest stages of AD. Expand
Regional Cerebral Blood Flow Abnormalities in Nondemented Patients With Memory Impairment
TLDR
It is demonstrated that subjects with an earlier onset of memory loss have an increased risk for developing AD, SPECT can be useful for distinguishing subjects with memory loss who will rapidly progress to AD from those who will not, and perfusion impairment typical of AD was evident even in Subjects with memory impairment who remained nondemented. Expand
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
TLDR
The result suggests a functional importance for the posterior cingulate cortex in impairment of learning and memory, which is a feature of very early Alzheimer's disease. Expand
Current concepts in mild cognitive impairment.
TLDR
A group of experts on aging and MCI from around the world in the fields of neurology, psychiatry, geriatrics, neuropsychology, neuroimaging, neuropathology, clinical trials, and ethics was convened to summarize the current state of the field of MCI. Expand
Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT.
TLDR
SPM analysis showed the characteristic early-AD rCBF pattern of selective decrease and longitudinal decline, which may be overlooked by a conventional region-of-interest technique with observer a priori choice and hypothesis, may closely relate to the pathophysiologic process of this disease. Expand
Hippocampal formation glucose metabolism and volume losses in MCI and AD
TLDR
Cross-sectional data show that in MCI hippocampal formation changes exist without significant neocortical changes, which best characterize AD, while in both MCI and AD, metabolism reductions exceed volume losses. Expand
Apolipoprotein E—associated risk for Alzheimer's disease in the African‐American population is genotype dependent
TLDR
The findings suggest that the association between ApoE σ4 and AD is weaker in African Americans than in whites. Expand
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