Mild and rapid Pd-catalyzed cross-coupling with hydrazine in continuous flow: application to the synthesis of functionalized heterocycles.

@article{Deangelis2013MildAR,
  title={Mild and rapid Pd-catalyzed cross-coupling with hydrazine in continuous flow: application to the synthesis of functionalized heterocycles.},
  author={Andrew Deangelis and Dong-hui Wang and Stephen L Buchwald},
  journal={Angewandte Chemie},
  year={2013},
  volume={52 12},
  pages={3434-7}
}
Functionalized arylhydrazines are of widespread importance as intermediates in the syntheses of nitrogen-containing heterocycles. In this regard, indoles, 2] arylpyrazoles/pyrazolones, 3] and aryltriazoles, among others, can be efficiently generated from arylhydrazines. These heterocyclic motifs are prevalent structural elements in numerous compounds of significant biological/medicinal value. Among current strategies to generate arylhydrazines, nucleophilic aromatic substitution to an aryl… CONTINUE READING