Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study

@article{Saxena2019MildPS,
  title={Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study},
  author={Neeraj Saxena and Tommaso Gili and Ana Diukova and Danielle L. Huckle and Judith E. Hall and Richard G. Wise},
  journal={Frontiers in Physiology},
  year={2019},
  volume={10}
}
Mechanisms of anesthetic drug-induced sedation and unconsciousness are still incompletely understood. Functional neuroimaging modalities provide a window to study brain function changes during anesthesia allowing us to explore the sequence of neuro-physiological changes associated with anesthesia. Cerebral perfusion change under an assumption of intact neurovascular coupling is an indicator of change in large-scale neural activity. In this experiment, we have investigated resting state cerebral… Expand
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References

SHOWING 1-10 OF 21 REFERENCES
Cerebral blood flow during propofol induced sedation.
TLDR
Data support the hypothesis that propofol preferentially alters CBF in specific brain regions necessary to maintain wakefulness, and this work determined if 2, 6-diisopropylphenol selectively affects cerebral blood flow in regions associated with wakefulness. Expand
Changes in Resting Neural Connectivity during Propofol Sedation
TLDR
This data show that connectivity of the posterior cingulate changes during sedation to include areas that are not traditionally considered to be part of the default mode network, such as the motor/somatosensory cortices, the anterior thalamic nuclei, and the reticular activating system. Expand
The Thalamus and Brainstem Act As Key Hubs in Alterations of Human Brain Network Connectivity Induced by Mild Propofol Sedation
TLDR
The effects of propofol, at a dose that produced mild sedation without loss of consciousness, on spontaneous cerebral activity of 15 healthy volunteers using functional magnetic resonance imaging (fMRI), exploiting oscillations in blood oxygenation level-dependent signal across functionally connected brain regions is investigated. Expand
Breakdown of within- and between-network Resting State Functional Magnetic Resonance Imaging Connectivity during Propofol-induced Loss of Consciousness
TLDR
It is suggested that propofol-induced unconsciousness could be linked to a breakdown of cerebral temporal architecture that modifies both within- and between-network connectivity and thus prevents communication between low-level sensory and higher-order frontoparietal cortices, thought to be necessary for perception of external stimuli. Expand
Multi-modal analysis of functional connectivity and cerebral blood flow reveals shared and unique effects of propofol in large-scale brain networks
TLDR
Altered connectivity in multiple large‐scale brain networks including the default mode (DMN), salience, visual, and motor networks and reduced CBF in the DMN, frontoparietal network, and thalamus is observed, suggesting that different modalities capture unique aspects of these large scale changes. Expand
Propofol anesthesia and cerebral blood flow changes elicited by vibrotactile stimulation: a positron emission tomography study.
TLDR
It is concluded that propofol interferes with the processing of vibrotactile information first at the level of the cortex before attenuating its transfer through the thalamus. Expand
Imaging the Effects of Propofol on Human Cerebral Glucose Metabolism Using Positron Emission Tomography
TLDR
Whole brain glucose metabolism was reduced during propofol anaesthesia; this was initially observed in the cortical areas at the lower dose but extended to the subcortical regions, especially the thalamus and hippocampus, at the higher dose, which suggests that these regions of the brain might be important targets that are susceptible to prop ofol. Expand
Propofol and Thiopental Do Not Interfere with Regional Cerebral Blood Flow Response at Sedative Concentrations
TLDR
The presence of propofol or thiopental does not affect the r CBF response to increasing stimulus rate during consciousness, and changes in rCBF activation patterns with sedative concentrations of these drugs represent effects on brain activity itself. Expand
Thiopental and propofol affect different regions of the brain at similar pharmacologic effects.
TLDR
Differences in regional cerebral blood flow (rCBF) were identified by using SPM99 analysis of images obtained with positron emission tomography with (15)O water to identify the loci of action for the nonsedative effects of propofol, such as amnesia. Expand
Reduced Dynamic Coupling Between Spontaneous BOLD-CBF Fluctuations in Older Adults: A Dual-Echo pCASL Study
TLDR
Interestingly, these results were observed in a group of elderlies with normal cognitive functions, suggesting that the study of dynamic BOLD-CBF coupling during resting-state is a promising technique, potentially able to provide early biomarkers of functional changes in the aging brain. Expand
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