Mild Plasmodium falciparum malaria following an episode of severe malaria is associated with induction of the interferon pathway in Malawian children.

@article{Krupka2012MildPF,
  title={Mild Plasmodium falciparum malaria following an episode of severe malaria is associated with induction of the interferon pathway in Malawian children.},
  author={Malkie Krupka and Karl Seydel and Catherine Manix Feintuch and Kenny M. Yee and Ryung S. Kim and Chang-Yun Lin and R Brent Calder and Christine H Petersen and Terrie Taylor and Johanna Daily},
  journal={Infection and immunity},
  year={2012},
  volume={80 3},
  pages={1150-5}
}
Infection with Plasmodium falciparum can lead to a range of severe to minimal symptoms, occasionally resulting in death in young children or nonimmune adults. In areas of high transmission, older children and adults generally suffer only mild or asymptomatic malaria infections and rarely develop severe disease. The immune features underlying this apparent immunity to severe disease remain elusive. To gain insight into host responses associated with severe and mild malaria, we conducted a… CONTINUE READING