Mild Electrical Stimulation with Heat Shock Ameliorates Insulin Resistance via Enhanced Insulin Signaling

  title={Mild Electrical Stimulation with Heat Shock Ameliorates Insulin Resistance via Enhanced Insulin Signaling},
  author={S. Morino and T. Kondo and K. Sasaki and H. Adachi and M. Suico and Erika Sekimoto and T. Matsuda and T. Shuto and E. Araki and H. Kai},
  journal={PLoS ONE},
  • S. Morino, T. Kondo, +7 authors H. Kai
  • Published 2008
  • Biology, Medicine
  • PLoS ONE
  • Low-intensity electrical current (or mild electrical stimulation; MES) influences signal transduction and activates phosphatidylinositol-3 kinase (PI3K)/Akt pathway. Because insulin resistance is characterized by a marked reduction in insulin-stimulated PI3K-mediated activation of Akt, we asked whether MES could increase Akt phosphorylation and ameliorate insulin resistance. In addition, it was also previously reported that heat shock protein 72 (Hsp72) alleviates hyperglycemia. Thus, we… CONTINUE READING
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