Mild Cognitive Impairment and Dementia

  title={Mild Cognitive Impairment and Dementia},
  author={Chenlu Gao and Michael K. Scullin and Donald L. Bliwise},
  journal={Handbook of Sleep Disorders in Medical Conditions},



Is Alzheimer's disease inevitable with age?: Lessons from clinicopathologic studies of healthy aging and very mild alzheimer's disease.

  • J. Morris
  • Medicine
    The Journal of clinical investigation
  • 1999
The unprecedented and growing number of older adults in the US and other developed countries has crystallized scientific interest in the health consequences of aging. Perhaps the most feared of these

2014 Alzheimer's disease facts and figures

Sleep disturbance is associated with incident dementia and mortality.

It is indicated that sleep disturbance may exist prior to the manifestation of other typical symptoms observed in AD (e.g., memory loss).

Vascular risk factors, incidence of MCI, and rates of progression to dementia

In this population, among those who progressed to dementia, 60% progressed to AD and 33% to VaD and there was a nonsignificant trend for stroke as a risk factor of progression of MCI to dementia.

Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1.

The prevalence of mild cognitive impairment and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study was determined, and specific subtypes of MCI were examined in detail only at the Pittsburgh, Pa, center.

Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study.

It is concluded that patients with mild cognitive impairment and depression are at more than twice the risk of developing dementia of Alzheimer type as those without depression.

Sleep architecture and the risk of incident dementia in the community

Despite contemporary interest in slow-wave sleep and dementia pathology, the findings implicate REM sleep mechanisms as predictors of clinical dementia.

Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons.

Sleep fragmentation in older adults is associated with incident AD and the rate of cognitive decline and was unchanged after controlling for potential confounders including total daily rest time, chronic medical conditions, and the use of common medications which can affect sleep.

Mild cognitive impairment: clinical characterization and outcome.

Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions.