Mild Acquired Thyroid Hormone Resistance Is Associated with Diabetes-Related Morbidity and Mortality in the General Population

@article{Guan2019MildAT,
  title={Mild Acquired Thyroid Hormone Resistance Is Associated with Diabetes-Related Morbidity and Mortality in the General Population},
  author={Haixia Guan},
  journal={Clinical Thyroidology},
  year={2019}
}
  • H. Guan
  • Published 9 April 2019
  • Medicine
  • Clinical Thyroidology

References

SHOWING 1-7 OF 7 REFERENCES
Hyperthyroxinemia is positively associated with prevalent and incident type 2 diabetes mellitus in two population-based samples from Northeast Germany and Denmark.
TLDR
Positive associations of thyroid hormones with prevalent and incident type 2 diabetes mellitus are demonstrated suggesting that hyperthyroxinemia may contribute to the pathogenesis of this condition.
Impaired Sensitivity to Thyroid Hormones Is Associated With Diabetes and Metabolic Syndrome
TLDR
Higher values in resistance to thyroid hormone indices are associated with obesity, metabolic syndrome, diabetes, and diabetes-related mortality, and these indices may facilitate monitoring treatments focused on energy balance.
Hypothyroidism Is a Risk Factor for New-Onset Diabetes: A Cohort Study
TLDR
Hypothyroidism is a risk factor for diabetes mellitus and subclinical hypothyroidistan-associated risk for DM is prominent only upon statin use, and identifying and treating hypothy thyroid hormone replacement therapy might reduce DM risk.
Relationship between serum thyrotropin concentrations and metformin therapy in euthyroid patients with type 2 diabetes
TLDR
Evaluated the interplay between metformin therapy and serum TSH concentrations in a group of patients with T2D and normal thyroid function to assess the effect of thyrotropin on thyroid function.
Thyroid Hormones and the Metabolic Syndrome
TLDR
It is evident that insulin sensitivity is highest and adverse thyroid effects on the metabolic system are lowest in euthyroid conditions, reflecting profound alterations of energy homeostasis at many levels.
Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.
TLDR
It is demonstrated that basal mitochondrial substrate oxidation is increased and energy production in the form of ATP synthesis is decreased in the muscle of RTH patients and that resting oxidative phosphorylation is uncoupled in this disorder.
TSH-Lowering Effect of Metformin in Type 2 Diabetic Patients
TLDR
Metformin administration influences TSH without change of FT4 in patients with type 2 diabetes and concomitant hypothyroidism, and the need for reevaluation of thyroid function in these patients within 6–12 months after starting metformin is indicated.