Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat.

Abstract

The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine (STR) produces reversible, segmentally localized allodynia in the rat. The purpose of this study was: (1) to investigate the effect of the anticonvulsant agent, milacemide, a glycine pro-drug on STR-allodynia; (2) to compare this effect with that of milacemide on normal nociception… (More)

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@article{Khandwala1998MilacemideAG, title={Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat.}, author={Hasnain M Khandwala and Caitlin Loomis}, journal={Pain}, year={1998}, volume={77 1}, pages={87-95} }