Migren patogenezinde oksidatif strese duyarlı TRP kanallarının rolleri

  title={Migren patogenezinde oksidatif strese duyarlı TRP kanallarının rolleri},
  author={Ahmi {\"O}z and Abd{\"u}lhadi Cihangir Uğuz},
Gunumuzde Turkiye nufusunun yaklasik olarak %17 sini etkileyen ve halk arasinda yayginligi gittikce artan bir hastalik olan migren tek tarafli bas agrisi ile karakterize edilmektedir. Vucutta fizyolojik sartlarda uretilen oksidan ajanlarla antioksidan molekuller arasindaki dengenin oksidan ajanlar lehine kaymasi oksidatif stres durumudur. Son yillarda sayisi hizla artan calismalarla oksidatif stresin migren patofizyolojisinde de temel rol oynayabilecegi iddiali bir sekilde bildirilmistir. Iyon… 
1 Citations

Thiol disulfide homeostasis as oxidative stress marker in migraine patients

Thiol-disulfide hemostasis is focused on, a new and reliable indicator in determining oxidative stress which is held responsible for the pathophysiology of migraine.



The TRPA1 channel in migraine mechanism and treatment

TRPA1 is emerging as a major contributing pathway in migraine and as a novel target for the development of drugs for pain and migraine treatment.

Molecular role of catalase on oxidative stress-induced Ca2+ signaling and TRP cation channel activation in nervous system

  • M. Nazıroğlu
  • Biology
    Journal of receptor and signal transduction research
  • 2012
It was observed that oxidative stress-induced activations of TRPM2, TRPM3, TRPC5 and TRPV1 cation channels in neuronal cells are modulated by catalase, suggesting antioxidant-dependent activation/inhibition of the channels.

TRPA1 and other TRP channels in migraine

TRP channels, and particularly TRPA1, may be proposed as novel pathways in migraine pathophysiology and as possible new targets for its treatment.

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators

It is shown that a variety of inflammatory mediators (15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), nitric oxide (NO), hydrogen peroxide (H2O2), and proton (H+) activate human TRPA1 heterologously expressed in HEK cells.

Vitamin E modulates oxidative stress and protein kinase C activator (PMA)-induced TRPM2 channel gate in dorsal root ganglion of rats

It is indicated that vitamin E modulated oxidative stress-induced TRPM2 channel activation in the DRG neurons and may be useful modulation of oxidative Stress-induced peripheral pain in sensory neurons.

Activation of transient receptor potential ankyrin 1 by hydrogen peroxide

It is shown that transient receptor potential ankyrin’1 (TRPA1), expressed by sensory neurons in the pain pathway, is a receptor for H2O2, and this results suggest that TRPA1 might be involved in the sensation of pain caused by H 2O2.

Nitric oxide activates TRP channels by cysteine S-nitrosylation

Findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families.

TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice

Genetic evidence is provided that the peripheral nociceptive action of NO is mediated by both TRPV1 and TRPA1, suggesting that production of endogenous levels of NO can activate these ion channels.