Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.

  title={Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.},
  author={Christoph Peter and Michaela Waibel and Caius G Radu and Li V Yang and Owen N Witte and Klaus Schulze-Osthoff and Sebastian Wesselborg and Kirsten Lauber},
  journal={The Journal of biological chemistry},
  volume={283 9},
Phagocytosis of apoptotic cells is fundamentally important throughout life, because non-cleared cells become secondarily necrotic and release intracellular contents, thus instigating inflammatory and autoimmune responses. Secreted "find-me" and exposed "eat-me" signals displayed by the dying cell in concert with the phagocyte receptors comprise the phagocytic synapse of apoptotic cell clearance. In this scenario, lysophospholipids (lysoPLs) are assumed to act as find-me signals for the… CONTINUE READING

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