Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma

@inproceedings{Srinivasainagendra2017MigrationOM,
  title={Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma},
  author={Vinodh Srinivasainagendra and Michael W Sandel and Bhupendra Singh and Aishwarya Sundaresan and Ved P. Mooga and Prachi Bajpai and Hemant K. Tiwari and Keshav K. Singh},
  booktitle={Genome Medicine},
  year={2017}
}
Colorectal adenocarcinomas are characterized by abnormal mitochondrial DNA (mtDNA) copy number and genomic instability, but a molecular interaction between mitochondrial and nuclear genome remains unknown. Here we report the discovery of increased copies of nuclear mtDNA (NUMT) in colorectal adenocarcinomas, which supports link between mtDNA and genomic instability in the nucleus. We name this phenomenon of nuclear occurrence of mitochondrial component as numtogenesis. We provide a description… CONTINUE READING
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