Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma

  title={Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma},
  author={Vinodh Srinivasainagendra and Michael W Sandel and Bhupendra Singh and Aishwarya Sundaresan and Ved P. Mooga and Prachi Bajpai and Hemant K. Tiwari and Keshav K. Singh},
  booktitle={Genome Medicine},
Colorectal adenocarcinomas are characterized by abnormal mitochondrial DNA (mtDNA) copy number and genomic instability, but a molecular interaction between mitochondrial and nuclear genome remains unknown. Here we report the discovery of increased copies of nuclear mtDNA (NUMT) in colorectal adenocarcinomas, which supports link between mtDNA and genomic instability in the nucleus. We name this phenomenon of nuclear occurrence of mitochondrial component as numtogenesis. We provide a description… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 51 times over the past 90 days. VIEW TWEETS
5 Extracted Citations
88 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 88 references

Similar Papers

Loading similar papers…