Migration of human blood dendritic cells across endothelial cell monolayers: adhesion molecules and chemokines involved in subset-specific transmigration.

@article{Rosa2003MigrationOH,
  title={Migration of human blood dendritic cells across endothelial cell monolayers: adhesion molecules and chemokines involved in subset-specific transmigration.},
  author={Gonzalo de la Rosa and Natividad Longo and Jos{\'e} Luis Rodr{\'i}guez-Fern{\'a}ndez and Amaya Puig-Kroger and Alfonso Pineda and {\'A}ngel L Corb{\'i} and Paloma S{\'a}nchez-Mateos},
  journal={Journal of leukocyte biology},
  year={2003},
  volume={73 5},
  pages={639-49}
}
Distinct subsets of dendritic cells (DCs) are present in blood, probably "en route" to different tissues. We have investigated the chemokines and adhesion molecules involved in the migration of myeloid (CD11c(+)) and plasmacytoid (CD123(+)) human peripheral blood DCs across vascular endothelium. Among blood DCs, the CD11c(+) subset vigorously migrated across endothelium in the absence of any chemotactic stimuli, whereas spontaneous migration of CD123(+) DCs was limited. In bare cell migration… CONTINUE READING