Migration of cytotoxic T lymphocytes toward melanoma cells in three-dimensional organotypic culture is dependent on CCL2 and CCR4.

@article{Zhang2006MigrationOC,
  title={Migration of cytotoxic T lymphocytes toward melanoma cells in three-dimensional organotypic culture is dependent on CCL2 and CCR4.},
  author={Tianqian Zhang and Rajasekharan Somasundaram and Klara Berencsi and Laura Caputo and Phyllis A. Gimotty and Pyapalli Rani and Dupont Guerry and Rolf Swoboda and Dorothee M. Herlyn},
  journal={European journal of immunology},
  year={2006},
  volume={36 2},
  pages={
          457-67
        }
}
Studies in experimental animal models have demonstrated that chemokines produced by tumor cells attract chemokine receptor-positive T lymphocytes into the tumor area. However, in cancer patients, the role of chemokines in T lymphocyte trafficking toward human tumor cells is relatively unexplored. In the present study, the migration of a melanoma patient's CTL toward autologous tumor cells has been studied in a novel three-dimensional organotypic melanoma culture. In this model, CTL migrated… CONTINUE READING
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