Migration of breast cancer cells: understanding the roles of volume exclusion and cell-to-cell adhesion.

@article{Simpson2010MigrationOB,
  title={Migration of breast cancer cells: understanding the roles of volume exclusion and cell-to-cell adhesion.},
  author={Matthew J. Simpson and Chris L Towne and D. L. Sean McElwain and Zee Upton},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  year={2010},
  volume={82 4 Pt 1},
  pages={
          041901
        }
}
We study MCF-7 breast cancer cell movement in a transwell apparatus. Various experimental conditions lead to a variety of monotone and nonmonotone responses which are difficult to interpret. We anticipate that the experimental results could be caused by cell-to-cell adhesion or volume exclusion. Without any modeling, it is impossible to understand the relative roles played by these two mechanisms. A lattice-based exclusion process random-walk model incorporating agent-to-agent adhesion is… CONTINUE READING

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