Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases.

@article{Son2006MigrationOB,
  title={Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases.},
  author={Bo-Ra Son and Leah A. Marquez-Curtis and Magda Kucia and Marcin Wysoczynski and A. Robert Turner and Janina Ratajczak and Mariusz Z Ratajczak and Anna Janowska-Wieczorek},
  journal={Stem cells},
  year={2006},
  volume={24 5},
  pages={
          1254-64
        }
}
Human mesenchymal stem cells (MSCs) are increasingly being considered in cell-based therapeutic strategies for regeneration of various organs/tissues. However, the signals required for their homing and recruitment to injured sites are not yet fully understood. Because stromal-derived factor (SDF)-1 and hepatocyte growth factor (HGF) become up-regulated during tissue/organ damage, in this study we examined whether these factors chemoattract ex vivo-expanded MSCs derived from bone marrow (BM) and… CONTINUE READING
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