Migration of V delta 1 and V delta 2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: competition by HIV-1 Tat.

@article{Poggi2004MigrationOV,
  title={Migration of V delta 1 and V delta 2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: competition by HIV-1 Tat.},
  author={Alessandro Poggi and Roberta Carosio and Daniela Fenoglio and Sabrina Brenci and Giuseppe Murdaca and Maurizio Setti and Francesco Indiveri and Silvia Scabini and Elisabetta Ferrero and Maria Raffaella Zocchi},
  journal={Blood},
  year={2004},
  volume={103 6},
  pages={2205-13}
}
We show that HIV-1-infected patients have increased concentrations of circulating V delta 1 T cells (2.2%-9.0% of T lymphocytes; healthy donors, 1.0%-2%) and, in some instances, V delta 2 T cells (3.5%-4.8% vs 2.0%-3.3%). In these patients, both V delta 1 and V delta 2 T cells are CXCR3+CXCR4+, whereas in healthy donors CXCR4 was preferentially expressed on V delta 1 T lymphocytes. gamma delta T cells transmigrated across endothelial monolayers, in response to interferon-gamma-inducing protein… CONTINUE READING

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