Migration of African trypanosomes across the blood-brain barrier.

  title={Migration of African trypanosomes across the blood-brain barrier.},
  author={Willias Masocha and Martin E Rottenberg and Krister Kristensson},
  journal={Physiology & behavior},
  volume={92 1-2},
Subspecies of the extracellular parasite, Trypanosoma brucei, which are spread by the tsetse fly in sub-Saharan Africa, cause in humans Sleeping Sickness. In experimental rodent models the parasite can at a certain stage of disease pass through the blood-brain barrier across or between the endothelial cells and the vessel basement membranes. The laminin composition of the basement membranes determines whether they are permissive to parasite penetration. One cytokine, interferon-gamma, plays an… CONTINUE READING
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