Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness.

@article{Lautscham2015MigrationIC,
  title={Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness.},
  author={Lena A. Lautscham and Christoph K{\"a}mmerer and Janina R. Lange and Thorsten Kolb and Christoph Mark and Achim Schilling and Pamela L. Strissel and Reiner Strick and Caroline Gluth and Amy C Rowat and Claus Metzner and Ben Fabry},
  journal={Biophysical journal},
  year={2015},
  volume={109 5},
  pages={900-13}
}
In cancer metastasis and other physiological processes, cells migrate through the three-dimensional (3D) extracellular matrix of connective tissue and must overcome the steric hindrance posed by pores that are smaller than the cells. It is currently assumed that low cell stiffness promotes cell migration through confined spaces, but other factors such as adhesion and traction forces may be equally important. To study 3D migration under confinement in a stiff (1.77 MPa) environment, we use soft… CONTINUE READING
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